The effect of different amine bases in the Swern oxidation of beta-amino alcohols

被引：14

作者：

Chrisman, W ^{[1
]}

Singaram, B ^{[1
]}

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM,THIMANN LABS,SANTA CRUZ,CA 95064

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 12期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)00283-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Swern oxidation of beta-amino alcohols containing tertiary amino groups afforded the corresponding alpha-amino carbonyl compounds in fair to excellent yield. Yields were dependent on the steric requirement of the amine base used for the reaction and were optimized by the use of N-methylpyrrolidine, N-ethylpiperidine, or triethylamine, depending on the beta-amino alcohol substrate. (C) 1997 Elsevier Science Ltd.

引用

页码：2053 / 2056

页数：4

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