Etiology and site of temporal lobe epilepsy influence postictal cytokine release

被引：101

作者：

Bauer, Sebastian ^{[1
]}

Cepok, Sabine ^{[2
]}

Todorova-Rudolph, Anelia ^{[3
]}

Nowak, Mareike ^{[1
]}

Koeller, Martina ^{[1
]}

Lorenz, Ruediger ^{[4
]}

Oertel, Wolfgang H. ^{[1
]}

Rosenow, Felix ^{[1
]}

Hemmer, Bernhard ^{[2
]}

Hamer, Hajo M. ^{[1
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35033 Marburg, Germany

[2] Tech Univ Munich, Dept Neurol, Munich, Germany

[3] Klinikum Weilmunster, Weilmunster, Germany

[4] Neuropediat & Epileptol Off, Bad Wildungen, Germany

来源：

EPILEPSY RESEARCH | 2009年 / 86卷 / 01期

关键词：

Temporal lobe epilepsy; IL-1; IL-6; TNF-alpha; Cytokines; Seizure; INCREASED PLASMA-LEVELS; FEBRILE SEIZURES; CEREBRAL OVEREXPRESSION; INFLAMMATORY CYTOKINES; RECEPTOR ANTAGONIST; CEREBROSPINAL-FLUID; TRANSGENIC MICE; KAPPA-B; INTERLEUKIN-6; IL-6;

D O I：

10.1016/j.eplepsyres.2009.05.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1 beta, IL-6 and TNF alpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying factors. Serum levels of IL-1 beta, IL-6 and TNF alpha were quantified by ELISA at baseline as well as immediately, 1 h and 24 h after a complex partial (CPS) or secondary generalized tonic-clonic seizure (GTCS) during video-EEG monitoring in 25 patients suffering from temporal epilepsy. IL-6 increased by 51% immediately after the seizure (p < 0.01) and remained elevated for 24h. This increase lacked in patients with hippocampal sclerosis (HS; n = 16, mean increase 28%, p > 0.5, vs. 112%, p < 0.01 in patients without HS). IL-6 levels were higher after right-sided seizures as compared to left-sided seizures 24h after the seizure (8.7 pg/mL vs. 3.4 pg/mL, p < 0.05). In patients taking valproate (VPA, n = 9), the levels of IL-1 p were higher as compared to patients not treated with VPA. The results suggest a relationship between the cytokine system and characteristics of TLE such as side and pathology. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：82 / 88

页数：7

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