Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis

被引：39

作者：

Harvey, D. ^{[1
]}

Pointon, J. J. ^{[1
]}

Sleator, C. ^{[2
]}

Meenagh, A. ^{[2
]}

Farrar, C. ^{[1
]}

Sun, J. Y. ^{[3
]}

Senitzer, D. ^{[3
]}

Middleton, D. ^{[2
]}

Brown, M. A. ^{[1
,4
]}

Wordsworth, B. P. ^{[1
]}

机构：

[1] Univ Oxford, Botnar Res Ctr, Inst Musculoskeletal Sci, Oxford, England

[2] City Hosp, No Ireland Reg Histocompatibil & Immunogenet Lab, Belfast, Antrim, North Ireland

[3] City Hope Natl Med Ctr, Div Haematol & Bone Marrow Transplantat, Duaete, CA USA

[4] Univ Queensland, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld, Australia

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2009年 / 68卷 / 04期

关键词：

CUTTING EDGE; CELL; HLA-B27; HLA; EXPRESSION; DIVERSITY; ARTHRITIS; KIR3DL2; NKB1;

D O I：

10.1136/ard.2008.095927

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objectives: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS). Methods: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the x 2 test. Results: KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls. Conclusions: Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.

引用

页码：595 / 598

页数：4

共 15 条

[1]

Cutting edge: Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures [J].