Amino acid N-carboxyanhydrides:: Activated peptide monomers behaving as phosphate-activating agents in aqueous solution

被引：42

作者：

Biron, JP ^{[1
]}

Pascal, R ^{[1
]}

机构：

[1] Univ Montpellier 2, Dept Chim, Organ Mol Evolut & Mat Fluores, UMR 5073,CC 017, F-34095 Montpellier, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 30期

关键词：

D O I：

10.1021/ja048189s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrolysis of valine N-carboxyanhydride (NCA) in aqueous phosphate buffers was shown to proceed through nucleophilic catalysis via an aminoacyl phosphate intermediate that displays phosphorylating capabilities through a potentially prebiotic process that simulates modern biochemical metabolic pathways. Copyright © 2004 American Chemical Society.

引用

页码：9198 / 9199

页数：2

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