The sheep genome illuminates biology of the rumen and lipid metabolism

被引：368

作者：

Jiang, Yu ^{[1
,2
,3
]}

Xie, Min ^{[4
]}

Chen, Wenbin ^{[4
]}

Talbot, Richard ^{[5
]}

Maddox, Jillian F. ^{[6
]}

Faraut, Thomas ^{[7
]}

Wu, Chunhua ^{[6
]}

Muzny, Donna M. ^{[8
]}

Li, Yuxiang ^{[4
]}

Zhang, Wenguang ^{[1
,9
,10
]}

Stanton, Jo-Ann ^{[11
]}

Brauning, Rudiger ^{[12
]}

Barris, Wesley C. ^{[2
]}

Hourlier, Thibaut ^{[13
,20
]}

Aken, Bronwen L. ^{[13
,20
]}

Searle, Stephen M. J. ^{[13
]}

Adelson, David L. ^{[2
]}

Bian, Chao ^{[4
]}

Cam, Graham R. ^{[2
]}

Chen, Yulin ^{[3
]}

Cheng, Shifeng ^{[4
]}

DeSilva, Udaya ^{[2
]}

Dixen, Karen ^{[14
]}

Dong, Yang ^{[1
]}

Fan, Guangyi ^{[4
]}

Franklin, Ian R. ^{[2
]}

Fu, Shaoyin ^{[9
]}

Fuentes-Utrilla, Pablo ^{[5
]}

Guan, Rui ^{[4
]}

Highland, Margaret A. ^{[15
,16
]}

Holder, Michael E. ^{[8
]}

Huang, Guodong ^{[4
]}

Ingham, Aaron B. ^{[2
]}

Jhangiani, Shalini N. ^{[8
]}

Kalra, Divya ^{[8
]}

Kovar, Christie L. ^{[8
]}

Lee, Sandra L. ^{[8
]}

Liu, Weiqing ^{[4
]}

Liu, Xin ^{[4
]}

Lu, Changxin ^{[4
]}

Lv, Tian ^{[4
]}

Mathew, Tittu ^{[8
]}

McWilliam, Sean ^{[2
]}

Menzies, Moira ^{[2
]}

Pan, Shengkai ^{[4
]}

Robelin, David ^{[7
]}

Servin, Bertrand ^{[7
]}

Townley, David ^{[2
]}

Wang, Wenliang ^{[4
]}

Wei, Bin ^{[4
,17
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China

[2] Commonwealth Sci & Ind Res Org Anim Food & Hlth S, St Lucia, Qld 4067, Australia

[3] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China

[4] BGI Shenzhen, Shenzhen 518083, Peoples R China

[5] Univ Edinburgh, Ediburgh Genom, Easter Bush EH25 9RG, Midlothian, Scotland

[6] Utah State Univ, Logan, UT 84322 USA

[7] INRA, Lab Genet Cellulaire, UMR 444, F-31326 Castanet Tolosan, France

[8] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[9] Inner Mongolia Agr Univ, Hohhot 010018, Peoples R China

[10] Nei Mongol Bioinformat, Inst ATCG, Hohhot, Peoples R China

[11] Univ Otago, Dept Anat, Dunedin 9054, New Zealand

[12] AgResearch, Invermay Agr Ctr, Mosgiel 9053, New Zealand

[13] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[14] Univ Copenhagen, Dept Biol, DK-2100 Copenhagen O, Denmark

[15] Washington State Univ, USDA ARS, Anim Dis Res Unit, Pullman, WA 99164 USA

[16] Washington State Univ, Dept Vet Microbiol & Pathol, Pullman, WA 99164 USA

[17] Sichuan Agr Univ, Maize Res Inst, Chengdu 611130, Peoples R China

[18] Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China

[19] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen N, Denmark

[20] European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SA, England

[21] Roslin Inst, Biosci Knowledge Transfer Network, Easter Bush EH25 9RG, Midlothian, Scotland

[22] Univ New England, Sch Environm & Rural Sci, Armidale, NSW 2351, Australia

[23] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia

[24] King Abdulaziz Univ, Princess Al Jawhara Ctr Excellence Res Hereditary, Jeddah 21589, Saudi Arabia

[25] Macau Univ Sci & Technol, Macau 999078, Peoples R China

[26] Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland

[27] Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9RG, Midlothian, Scotland

来源：

SCIENCE | 2014年 / 344卷 / 6188期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

PROLINE-RICH PROTEINS; IDENTIFICATION; EVOLUTIONARY; EXPRESSION; ENVELOPES; RUMINANT; GENES; SITE; FAT;

D O I：

10.1126/science.1252806

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

引用

页码：1168 / 1173

页数：6

共 24 条

[1] ENERGY CONTRIBUTIONS OF VOLATILE FATTY-ACIDS FROM THE GASTROINTESTINAL-TRACT IN VARIOUS SPECIES [J].

BERGMAN, EN .

PHYSIOLOGICAL REVIEWS, 1990, 70 (02) :567-590

[2] Invited review: Pathology, etiology, prevention, and treatment of fatty liver in dairy cows [J].

Bobe, G ;

Young, JW ;

Beitz, DC .

JOURNAL OF DAIRY SCIENCE, 2004, 87 (10) :3105-3124

[3] Identification of acyl coenzyme A:Monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption [J].

Cheng, D ;

Nelson, TC ;

Chen, J ;

Walker, SG ;

Wardwell-Swanson, J ;

Meegalla, R ;

Taub, R ;

Billheimer, JT ;

Ramaker, M ;

Feder, JN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (16) :13611-13614

[4] A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep [J].

Clop, Alex ;

Marcq, Fabienne ;

Takeda, Haruko ;

Pirottin, Dimitri ;

Tordoir, Xavier ;

Bibe, Bernard ;

Bouix, Jacques ;

Caiment, Florian ;

Elsen, Jean-Michel ;

Eychenne, Francis ;

Larzul, Catherine ;

Laville, Elisabeth ;

Meish, Francoise ;

Milenkovic, Dragan ;

Tobin, James ;

Charlier, Carole ;

Georges, Michel .

NATURE GENETICS, 2006, 38 (07) :813-818

[5] Distinct roles for amino- and carboxyl-terminal sequences of SPRR1 protein in the formation of cross-linked envelopes of conducting airway epithelial cells [J].

Deng, J ;

Pan, RQ ;

Wu, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (08) :5739-5747

[6] The Origins of C4 Grasslands: Integrating Evolutionary and Ecosystem Science [J].

Edwards, Erika J. ;

Osborne, Colin P. ;

Stroemberg, Caroline A. E. ;

Smith, Stephen A. ;

Bond, William J. ;

Christin, Pascal-Antoine ;

Cousins, Asaph B. ;

Duvall, Melvin R. ;

Fox, David L. ;

Freckleton, Robert P. ;

Ghannoum, Oula ;

Hartwell, James ;

Huang, Yongsong ;

Janis, Christine M. ;

Keeley, Jon E. ;

Kellogg, Elizabeth A. ;

Knapp, Alan K. ;

Leakey, Andrew D. B. ;

Nelson, David M. ;

Saarela, Jeffery M. ;

Sage, Rowan F. ;

Sala, Osvaldo E. ;

Salamin, Nicolas ;

Still, Christopher J. ;

Tipple, Brett .

SCIENCE, 2010, 328 (5978) :587-591

[7] The role of epidermal lipids in cutaneous permeability barrier homeostasis [J].

Feingold, Kenneth R. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (12) :2531-2546

[8] Invited review: Ruminant ecology and evolution: Perspectives useful to ruminant livestock research and production [J].

Hackmann, T. J. ;

Spain, J. N. .

JOURNAL OF DAIRY SCIENCE, 2010, 93 (04) :1320-1334

[9] Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver [J].

Hall, Angela M. ;

Kou, Kou ;

Chen, Zhouji ;

Pietka, Terri A. ;

Kumar, Mrudula ;

Korenblat, Kevin M. ;

Lee, Kyuha ;

Ahn, Kay ;

Fabbrini, Elisa ;

Klein, Samuel ;

Goodwin, Bryan ;

Finck, Brian N. .

JOURNAL OF LIPID RESEARCH, 2012, 53 (05) :990-999

[10] EVOLUTIONARY STEPS OF ECOPHYSIOLOGICAL ADAPTATION AND DIVERSIFICATION OF RUMINANTS - A COMPARATIVE VIEW OF THEIR DIGESTIVE-SYSTEM [J].

HOFMANN, RR .

OECOLOGIA, 1989, 78 (04) :443-457

← 1 2 3 →