Dietary flavonoids: effects on endothelial function and blood pressure

被引:84
作者
Hodgson, Jonathan M. [1 ]
Croft, Kevin D.
机构
[1] Univ Western Australia, Sch Med & Pharmacol, GPO Box X2213, Perth, WA 6001, Australia
[2] Western Australian Inst Med Res, Perth, WA, Australia
关键词
flavonoids; endothelial function; blood pressure; metabolism;
D O I
10.1002/jsfa.2675
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Several population studies have found an inverse association between flavonoid intake and risk of cardiovascular disease. These studies have resulted in the hypothesis that dietary flavonoids protect against cardiovascular disease. Many in vitro studies, studies using animal models and human intervention trials have been carried out to investigate how flavonoids might provide protection. Emerging and largely consistent evidence suggests that flavonoids can improve endothelial function and may reduce blood pressure. In vitro studies show that a variety of flavonoids cause vasorelaxation of isolated arteries from rats. In human intervention trials, flavonoids derived from tea and cocoa or dark chocolate - both rich sources of catechins - have been found to improve endothelial function acutely and with regular ingestion. The evidence for benefits of flavonoids from other dietary sources is less clear. Improvements in endothelial function could contribute to lower blood pressure. Population studies have associated higher intake of tea and chocolate with lower blood pressure. Short-term intervention studies in humans have shown blood pressure lowering with cocoa or dark chocolate, but short-term regular ingestion of tea has not been found to lower blood pressure. The long-term effects of regular ingestion of a flavonoid-enriched diet on endothelial function and blood pressure have yet to be assessed. In addition, there is evidence that flavonoid metabolism is an important factor influencing the biological activity and effects of dietary flavonoids, but further studies are needed to investigate this area. (c) 2006 Society of Chemical Industry
引用
收藏
页码:2492 / 2498
页数:7
相关论文
共 89 条
[81]  
Waddington E, 2004, AM J CLIN NUTR, V79, P54
[82]  
Walker HA, 2001, CIRCULATION, V103, P258, DOI 10.1161/01.CIR.103.2.258
[83]   The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial [J].
Ward, NC ;
Hodgson, JM ;
Croft, KD ;
Burke, V ;
Bellin, LJ ;
Puddey, IB .
JOURNAL OF HYPERTENSION, 2005, 23 (02) :427-434
[84]   Effects of white and red wine on endothelial function in subjects with coronary artery disease [J].
Whelan, AP ;
Sutherland, WHF ;
McCormick, MP ;
Yeoman, DJ ;
de Jong, SA ;
Williams, MJA .
INTERNAL MEDICINE JOURNAL, 2004, 34 (05) :224-228
[85]   Refiguring the nature of undeclared work - Some evidence from England [J].
Williams, CC ;
Windebank, J .
EUROPEAN SOCIETIES, 2005, 7 (01) :81-102
[86]   Vascular and anti-oxidant actions of flavonols and flavones [J].
Woodman, OL ;
Chan, EC .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2004, 31 (11) :786-790
[87]   The protective effect of habitual tea consumption on hypertension [J].
Yang, YC ;
Lu, FH ;
Wu, JS ;
Wu, CH ;
Chang, CJ .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (14) :1534-1540
[88]   Soy food consumption is associated with lower risk of coronary heart disease in Chinese women [J].
Zhang, XL ;
Shu, XO ;
Gao, YT ;
Yang, G ;
Li, Q ;
Li, HL ;
Jin, F ;
Zheng, W .
JOURNAL OF NUTRITION, 2003, 133 (09) :2874-2878
[89]   Red wine and beer elevate blood pressure in normotensive men [J].
Zilkens, RR ;
Burke, V ;
Hodgson, JM ;
Barden, A ;
Beilin, LJ ;
Puddey, IB .
HYPERTENSION, 2005, 45 (05) :874-879