Catalytic asymmetric hydroxymethylation of silicon enolates using an aqueous solution of formaldehyde with a chiral scandium complex

被引：148

作者：

Ishikawa, S ^{[1
]}

Hamada, T ^{[1
]}

Manabe, K ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 39期

关键词：

D O I：

10.1021/ja047896i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic asymmetric hydroxymethylation of silicon enolates has been achieved. In this reaction, an aqueous solution of formaldehyde can be used to realize an easy and safe procedure, and high enantioselectivities have been obtained. This is the first example of catalytic asymmetric reactions in aqueous media with a chiral scandium complex. Copyright © 2004 American Chemical Society.

引用

页码：12236 / 12237

页数：2

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