The growth advantage in stationary-phase (GASP) phenomenon in mixed cultures of enterobacteria

被引:15
作者
Bacun-Druzina, Visnja
Cagalj, Zeljka
Gjuracic, Kresimir
机构
[1] Univ Zagreb, Fac Food Technol & Biotechnol, Lab Biol & Microbial Genet, HR-10001 Zagreb, Croatia
[2] PLIVA, Res Inst Ltd, Zagreb, Croatia
关键词
growth advantage in stationary phase; GASP; Escherichia coli; Salmonella enterica; streptomycin resistance; nalidixic acid resistance;
D O I
10.1111/j.1574-6968.2006.00515.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Growth advantage in stationary phase (GASP) is the term used to describe the ability of mutants with an increased fitness from 10-day-old enterobacteria culture to outcompete 1-day-old cells of the same initial strain during a prolonged stationary phase, although the aged cells are introduced as a minority. We studied this bacterial trait in mixed cultures of two enterobacterial species, Escherichia coli and Salmonella enterica, wild type in addition to derived mutants from both strains that contain chromosomal-encoded resistance to either nalidixic acid or streptomycin. The strong GASP phenotype was obtained in mixed cultures with the aged mutant strains, but not when the isogenic antibiotic-sensitive strains were used. This phenomenon was associated with chromosomal rearrangements in 10-day-old bacterial antibiotic-resistant mutated cells.
引用
收藏
页码:119 / 127
页数:9
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