MECHANISMS OF DISEASE Cell Death

被引：938

作者：

Hotchkiss, Richard S. ^{[1
,2
,3
]}

Strasser, Andreas ^{[4
]}

McDunn, Jonathan E. ^{[1
]}

Swanson, Paul E. ^{[5
]}

机构：

[1] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[4] Walter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Melbourne, Vic 3050, Australia

[5] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 361卷 / 16期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

BH3-ONLY PROTEINS PUMA; TUMOR NECROSIS FACTOR; INDUCED APOPTOSIS; CANCER-THERAPY; CYTOCHROME-C; PHARMACOLOGICAL MANIPULATION; MEMBRANE PERMEABILIZATION; AUTOREACTIVE THYMOCYTES; CEREBRAL-ISCHEMIA; ADOPTIVE TRANSFER;

D O I：

10.1056/NEJMra0901217

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy. Copyright © 2009 Massachusetts Medical Society.

引用

页码：1570 / 1583

页数：14

共 128 条

[71] The role of calpain in oncotic cell death [J].

Liu, XL ;

Van Vleet, T ;

Schnellmann, RG .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :349-370

[72] The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory [J].

Loepke, Andreas W. ;

Istaphanous, George K. ;

McAuliffe, John J., III ;

Miles, Lili ;

Hughes, Elizabeth A. ;

McCann, John C. ;

Harlow, Kathryn E. ;

Kurth, C. Dean ;

Williams, Michael T. ;

Vorhees, Charles V. ;

Danzer, Steve C. .

ANESTHESIA AND ANALGESIA, 2009, 108 (01) :90-104

[73] Targeted therapy for cancer using PARP inhibitors [J].

Lord, Christopher J. ;

Ashworth, Alan .

CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (04) :363-369

[74] Activation and caspase-mediated inhibition of PARP: A molecular switch between fibroblast necrosis and apoptosis in death receptor signaling [J].

Los, M ;

Mozoluk, M ;

Ferrari, D ;

Stepczynska, A ;

Stroh, C ;

Renz, A ;

Herceg, Z ;

Wang, ZQ ;

Schulze-Osthoff, K .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (03) :978-988

[75] High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal [J].

Lotze, MT ;

Tracey, KJ .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (04) :331-342

[76] An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury [J].

Luke, Cliff J. ;

Pak, Stephen C. ;

Askew, Yuko S. ;

Naviglia, Terra L. ;

Askew, David J. ;

Nobar, Shila M. ;

Vetica, Anne C. ;

Long, Olivia S. ;

Watkins, Simon C. ;

Stolz, Donna B. ;

Barstead, Robert J. ;

Moulder, Gary L. ;

Bromme, Dieter ;

Silverman, Gary A. .

CELL, 2007, 130 (06) :1108-1119

[77] IKK/NF-κB signaling: balancing life and death -: a new approach to cancer therapy [J].

Luo, JL ;

Kamata, H ;

Karin, M .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (10) :2625-2632

[78] Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis (vol 118, pg 79, 2008) [J].

Maclean, Kirsteen H. ;

Dorsey, Frank C. ;

Cleveland, John L. ;

Kastan, Michael B. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (04) :1584-1584

[79] Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis [J].

Maclean, Kirsteen H. ;

Dorsey, Frank C. ;

Cleveland, John L. ;

Kastan, Michael B. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :79-88

[80] Control of autophagy by oncogenes and tumor suppressor genes [J].

Maiuri, M. C. ;

Tasdemir, E. ;

Criollo, A. ;

Morselli, E. ;

Vicencio, J. M. ;

Carnuccio, R. ;

Kroemer, G. .

CELL DEATH AND DIFFERENTIATION, 2009, 16 (01) :87-93

← 3 4 5 6 7 8 9 10 11 12 →