Immunomodulatory action of levofloxacin on cytokine production by human peripheral blood mononuclear cells

被引：51

作者：

Yoshimura, T ^{[1
]}

Kurita, C ^{[1
]}

Usami, E ^{[1
]}

Nakao, T ^{[1
]}

Watanabe, S ^{[1
]}

Kobayashi, J ^{[1
]}

Yamazaki, F ^{[1
]}

Nagai, H ^{[1
]}

机构：

[1] GIFU PHARMACEUT UNIV, DEPT PHARMACOL, GIFU 502, JAPAN

来源：

CHEMOTHERAPY | 1996年 / 42卷 / 06期

关键词：

levofloxacin; interleukin-2; interleukin-1; beta; tumor necrosis factor-alpha; mononuclear cell;

D O I：

10.1159/000239480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Levofloxacin (LVFX), the bacteriologically active isomer of ofloxacin, is a fluorinated quinolone. LVFX suppressed the proliferative activity of peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA). LVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 mu g/ml of LVFX causing a significant increase. The granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by PHA-stimulated PBMC was suppressed at high concentrations of LVFX. Interleukin-1 beta production by lipopolysaccharide-stimulated PBMC was suppressed in a concentration-dependent manner by LVFX, and tumor necrosis factor-alpha production was suppressed at only the highest concentration. In contrast, interleukin-8 production was little affected by LVFX. These results show that LVFX has action on cytokines production by PBMC independent of its antimicrobial activity.

引用

页码：459 / 464

页数：6

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