Bacillus subtilis genome diversity

被引：80

作者：

Earl, Ashlee M.

Losick, Richard

Kolter, Roberto

机构：

[1] Harvard Univ, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[2] Harvard Univ, Biol Labs, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 03期

关键词：

D O I：

10.1128/JB.01343-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains belonging to the nonpathogenic species Bacillus subtilis. Our M-CGH results indicate that there is considerable genetic heterogeneity among members of this species; nearly one-third of Bsu168-specific genes exhibited variability, as measured by the microarray hybridization intensities. The variable loci include those encoding proteins involved in antibiotic production, cell wall synthesis, sporulation, and germination. The diversity in these genes may reflect this organism's ability to survive in diverse natural settings.

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收藏

页码：1163 / 1170

页数：8

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