Ceratinamides A and B: New antifouling dibromotyrosine derivatives from the marine sponge Pseudoceratina purpurea

被引：104

作者：

Tsukamoto, S ^{[1
]}

Kato, H ^{[1
]}

Hirota, H ^{[1
]}

Fusetani, N ^{[1
]}

机构：

[1] NIIGATA ENGN CO LTD,EXPLORATORY RES ADV TECHNOL,FUSETANI BIOFOULING PROJECT,RES DEV CORP JAPAN,YOKOHAMA,KANAGAWA 235,JAPAN

来源：

TETRAHEDRON | 1996年 / 52卷 / 24期

关键词：

D O I：

10.1016/0040-4020(96)00387-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ceratinamides A and B (1 and 2), new bromotyrosine derivatives, have been isolated from the marine sponge Pseudoceratina purpurea, along with the known psammaplysins A (3) and E (4), ceratinamine (5), moloka'iamine (6), pseudoceratidine (7), and 4,5-dibromopyrrole-2-carbamide (8). Their structures were elucidated on the basis of spectral data. Compounds 1-7 inhibited larval settlement and metamorphosis of the barnacle Balanus amphitrite with ED(50) values of 0.10-8.0 mu g/mL, while compounds 3 and 8 induced larval metamorphosis of the ascidian Halocynthia roretzi at concentrations of 1.2 and 25 mu g/mL, respectively. Compounds 5 and 6 also showed cytotoxicity against P388 murine leukemia cells with IC50 values of 3.4 and 2.1 mu g/mL, respectively; 7 was antibacterial against Flavobacterium marinotypicum. Copyright (C) 1996 Elsevier Science Ltd

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页码：8181 / 8186

页数：6

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