Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TICI single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging

被引:35
作者
Kimura, T
Sako, K
Tanaka, K
Gotoh, T
Yoshida, H
Aburano, T
Tanaka, T
Arai, H
Nakada, T
机构
[1] Niigata Univ, Brain Res Inst, Ctr Integrated Human Brain Sci, Niigata 9518585, Japan
[2] Niigata Neurosurg Hosp, Dept Neurosurg, Niigata, Japan
[3] Brain Res Ctr, Niigata, Japan
[4] Asahikawa Med Coll, Dept Neurosurg, Asahikawa, Hokkaido 078, Japan
[5] Asahikawa Med Coll, Cent Lab Res & Educ, Dept Radiol, Asahikawa, Hokkaido 078, Japan
关键词
proton magnetic resonance spectroscopy metastatic brain tumor; stereotactic radiosurgery; gadolinium-enhanced magnetic resonance imaging thallium-201 chloride single-photon emission computerized tomography;
D O I
10.3171/jns.2004.100.5.0835
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Object. The goal of this study was to investigate the usefulness of proton (H-1) magnetic resonance (MR) spectroscopy to evaluate the response of metastatic brain tumors to stereotactic radiosurgery (SRS) in comparison with Gd-enhanced MR imaging and single-photon emission computerized tomography with administration of thallium-201 chloride ((TlCl)-Tl-201-SPECT). Methods. Forty patients with a total of 47 metastatic brain tumors were evaluated. The primary lesion was identified in all cases. Stereotactic radiosurgery was effective in 37 lesions. All patients were examined using Gd-enhanced MR imaging before and after SRS. Thalium-201 chloride was administered to 27 patients with 34 tumors and SPECT images were obtained. Proton MR spectroscopy was performed in 36 patients who harbored 43 tumors. On Gd-enhanced MR images, a decrease in the volume of the Gd-enhanced lesion and a change in the enhanced effect in the lesion after treatment were recognized as showing the effectiveness of SRS between I and 3 months or more (mean 8.54 +/- 3.58 weeks). In (TlCl)-Tl-201-SPECT studies, the ratio of lesion to normal brain decreased from 2 weeks to 2 months (mean 5.03 +/- 2.77 weeks) after radiosurgery. On H-1-MR spectroscopy images a high choline (Cho) peak and a lipid-dominant (Lip) peak were observed in 25 lesions and a high Cho peak and a lactate-dominant (Lac) peak were observed in 12 lesions before SRS. A decrease in the Cho peak, a disappearance of the Lac peak. and an increase in the Lip peak were observed between I week and I month (mean 2.76 +/- 1.62 weeks) after treatment. Conclusions. Based on histopathological findings obtained at autopsy or at surgery, we assume that a high Cho peak may be observed in viable tumor tissue and a Lip peak in areas of necrosis. The results indicate that H-1-MR spectroscopy is potentially a more sensitive tool in evaluating the response to SRS than (TlCl)-Tl-201-SPECT or Gd-enhanced MR imaging and that it can be used earlier for this purpose than those other imaging methods.
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页码:835 / 841
页数:7
相关论文
共 15 条
  • [11] Volume MRI and MRSI techniques for the quantitation of treatment response in brain tumors: Presentation of a detailed case study
    Nelson, SJ
    Huhn, S
    Vigneron, DB
    Day, MR
    Wald, LL
    Prados, M
    Chang, S
    Gutin, PH
    Sneed, PK
    Verhey, L
    Hawkins, RA
    Dillon, WP
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (06) : 1146 - 1152
  • [12] Seo Yoshinobu, 1997, Neurologia Medico-Chirurgica, V37, P25, DOI 10.2176/nmc.37.25
  • [13] A METHOD FOR VOLUME-LOCALIZED LACTATE EDITING USING ZERO-QUANTUM COHERENCE CREATED IN A STIMULATED-ECHO PULSE SEQUENCE
    SOTAK, CH
    FREEMAN, DM
    [J]. JOURNAL OF MAGNETIC RESONANCE, 1988, 77 (02): : 382 - 388
  • [14] LINAC RADIOSURGERY - AN ANIMAL-MODEL
    SPIEGELMANN, R
    FRIEDMAN, WA
    BOVA, FJ
    THEELE, DP
    MICKLE, JP
    [J]. JOURNAL OF NEUROSURGERY, 1993, 78 (04) : 638 - 644
  • [15] THOMPSON BG, 1990, SURG NEUROL, V33, P96