Synthesis and radioprotective action of silathiazolidines and germathiazolidines

被引：1

作者：

Célariès, B

Amourette, C

Lion, C

Rima, G

机构：

[1] Univ Toulouse 3, LHFA, UMR 5069, CNRS, F-31062 Toulouse 4, France

[2] Ctr Rech Serv Sante Armees, F-38702 La Tronche, France

[3] Univ Paris 07, ITODYS, CNRS, F-75005 Paris, France

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2004年 / 18卷 / 06期

关键词：

silathiazolidines; germathiazolidines; naphthylethylimidazoline; toxicity; LD50; radioprotective activity;

D O I：

10.1002/aoc.622

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report on the synthesis and characterization of new sila- and germa-thiazolidines derived from 2-[1-(1-naphthyl)methy]-2-imidazoline. The radioprotective activity was evaluated in mice by intraperitoneal injection.. A notable diminution in the toxicity and increase in radioprotective efficacy were shown for the organometallic derivatives compared with the unsubstituted organic precursors. For some of the cyclic compounds, a delay effect was observed tranducing a slow opening in vivo of the thiazolidine ring. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：291 / 297

页数：7

共 22 条

[21] Pharmacological discrimination between enantiomeric germanes by muscarinic receptors: A study on germanium/silicon bioisosterism [J].