Minisatellite mutational processes reduce Fst estimates

被引:37
作者
Flint, J
Bond, J
Rees, DC
Boyce, AJ
Roberts-Thomson, JM
Excoffier, L
Clegg, JB
Beaumont, MA
Nichols, RA
Harding, RM [1 ]
机构
[1] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England
[2] Univ Oxford, Dept Biol Anthropol, Oxford, England
[3] Univ Geneva, Dept Anthropol, Genet & Biometry Lab, Geneva 24, Switzerland
[4] Zool Soc London, Inst Zool, London NW1 4RY, England
[5] Univ London, QMW, Sch Biol Sci, London, England
基金
英国惠康基金;
关键词
D O I
10.1007/s004390051147
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We have used a new method for binning minisatellite alleles (semi-automated allele aggregation) and report the extent of population diversity detectable by eleven minisatellite loci in 2689 individuals from 19 human populations distributed widely throughout the world. Whereas population relationships are consistent with those found in other studies, our estimate of genetic differentiation (F-st) between populations is less than 8%, which is lower than comparative estimates of between 10%-15% obtained by using other sources of polymorphism data. We infer that mutational processes are involved in reducing F-st estimates from minisatellite data because, first, the lowest F-st estimates are found at loci showing autocorrelated frequencies among alleles of similar size and, second, F-st declines with heterozygosity but by more than predicted assuming simple models of mutation. These conclusions are consistent with the view that minisatellites are subject to selective or mutational constraints in addition to those expected under simple stepwise mutation models.
引用
收藏
页码:567 / 576
页数:10
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