Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy

被引：50

作者：

Griffiths, JR ^{[1
]}

Glickson, JD

机构：

[1] St George Hosp, Sch Med, Dept Biochem & Immunol, Canc Res Campaign,Biomed Magnet Resonance Res Grp, London SW17 0RE, England

[2] Univ Penn, Sch Med, Dept Radiol, Stellar Chance Labs B1, Philadelphia, PA 19104 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2000年 / 41卷 / 01期

关键词：

pharmacodynamics; pharmacokinetics; magnetic resonance spectroscopy; anticancer drugs;

D O I：

10.1016/S0169-409X(99)00057-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Magnetic resonance spectroscopy (MRS) offers the unique advantage of detecting, identifying and quantifying chemicals deep within the living body in a totally non-invasive manner. In studies on pharmacology and toxicology of anticancer drugs, MRS and the closely related technique magnetic resonance imaging (MRI) have many uses. MRS in particular, despite its low sensitivity, offers unique insights into pharmacokinetics (the changing concentration of the drug at its site of action) which can be monitored, and metabolism (both activation and detoxification) can be detected in real time. This review considers some recent work on F-19, (31)p, H-1 and C-13 MRS Of anticancer drugs. Future possibilities for C-13 MRS and H-1 MRS studies of drugs and their metabolites are considered in detail. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：75 / 89

页数：15

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