Mobilization of qnrB2 and ISCR1 in Plasmids

被引：47

作者：

Chen, Ying-Tsong ^{[1
]}

Liao, Tsai-Lien ^{[1
]}

Liu, Yen-Ming ^{[1
]}

Lauderdale, Tsai-Ling ^{[2
]}

Yan, Jing-Jou ^{[3
]}

Tsai, Shih-Feng ^{[1
,4
,5
,6
,7
]}

机构：

[1] Natl Hlth Res Inst, Div Mol & Genom Med, Miaoli, Taiwan

[2] Natl Hlth Res Inst, Div Clin Res, Miaoli, Taiwan

[3] Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan

[4] Natl Yang Ming Univ, Genome Res Ctr, Taipei 112, Taiwan

[5] Natl Yang Ming Univ, Inst Biomed Informat, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan

[7] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 03期

关键词：

MEDIATED QUINOLONE RESISTANCE; COMPLETE NUCLEOTIDE-SEQUENCE; ANTIBIOTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; COMPARATIVE GENOMICS; ESCHERICHIA-COLI; TRANSPOSITION; PREVALENCE; INTEGRON; GENES;

D O I：

10.1128/AAC.00970-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.

引用

页码：1235 / 1237

页数：3

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