Obesity and cancer

被引：501

作者：

Calle, EE ^{[1
]}

Thun, MJ ^{[1
]}

机构：

[1] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA

来源：

ONCOGENE | 2004年 / 23卷 / 38期

关键词：

anthropometry; body mass index; cancer; epidemiology; obesity; overweight;

D O I：

10.1038/sj.onc.1207751

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large prospective studies show a significant association with obesity for several cancers, and the International Agency for Research on Cancer has classified the evidence of a causal link as 'sufficient' for cancers of the colon, female breast (postmenopausal), endometrium, kidney (renal cell), and esophagus (adenocarcinoma). These data, and the rising worldwide trend in obesity, suggest that overeating may be the largest avoidable cause of cancer in nonsmokers. Few obese people are successful in long-term weight reduction, and thus there is little direct evidence regarding the impact of weight reduction on cancer risk. If the correlation between obesity and cancer mortality is entirely causal, we estimate that overweight and obesity now account for one in seven of cancer deaths in men and one in five in women in the US.

引用

页码：6365 / 6378

页数：14

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