The effect of sulfur-metabolising bacteria on sulfur-containing psychotropic drugs

被引：11

作者：

Batziris, HP ^{[1
]}

McIntyre, IM ^{[1
]}

Drummer, OH ^{[1
]}

机构：

[1] Monash Univ, Dept Forens Med, Victorian Inst Forens Med, Melbourne, Vic 3006, Australia

来源：

INTERNATIONAL BIODETERIORATION & BIODEGRADATION | 1999年 / 44卷 / 2-3期

关键词：

bacteria; drug degradation; postmortem; psychotropic drugs; forensic toxicology;

D O I：

10.1016/S0964-8305(99)00066-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eight bacterial species commonly found in postmortem specimens were assessed for their ability to degrade three sulfur-containing psychotropic drugs (chlorpromazine, thioridazine and dothiepin). The two species investigated (Proteus mirabilis and Clostridium perfringens) did not mediate degradation of the drugs when incubated individually over an 8-h period at 37 degrees C in separate blood specimens containing each of the drugs. However, separate experiments demonstrated that degradation of these drugs did occur in decomposed blood and liver specimens. Such studies suggest that other bacteria or other factors may be responsible for drug decomposition. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：111 / 116

页数：6