Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine?

被引:82
作者
Haddad, JJ [1 ]
Fahlman, CS [1 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Anesthesia & Perioperat Care, Mol Neurosci Res Div,Severinghaus Radiometer Res, San Francisco, CA 94143 USA
关键词
antioxidant; cytokines; IL-10; glutathione; reactive oxygen/nitrogen species; redox regulation; transcription factors;
D O I
10.1016/S0006-291X(02)02094-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reduction-oxidation (redox) state constitutes such a potential signaling mechanism for the regulation of an inflammatory signal associated with oxidative stress. Interleukin (IL)-10 has recently emerged as an anti-inflammatory cytokine with antioxidant properties. Interestingly, redox- and oxidant-mediated pathways positively and/or negatively regulate the expression, distribution, and functional properties of IL-10, thus, allowing the evolution of what is known as an anti-inflammatory redox-oxidant revolving axis. This axis is directly involved in regulating phosphorylation mechanisms, which eventually control gene expression and the biosynthesis of oxidative stress-related cofactors, such as reactive species and inflammatory cytokines. The association between IL-10, an anti-inflammatory antioxidant, with redox- and oxidant-related pathways governing the regulation of inflammatory and closely dependent processes is thereafter discussed. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:163 / 176
页数:14
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