Identification of inhibitors of inducible nitric oxide synthase from microbial extracts

被引：21

作者：

Alvi, KA ^{[1
]}

Baker, DD ^{[1
]}

Stienecker, V ^{[1
]}

Hosken, M ^{[1
]}

Nair, BG ^{[1
]}

机构：

[1] MDS PANLABS, Bothell, WA 98011 USA

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 05期

关键词：

D O I：

10.7164/antibiotics.53.496

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new member of the angucycline family, vineomycin C (3), together with four known metabolites saquayamycin A1 (1), A-7884 (2), rabelomycin (5) and xanthomegnin (6) were isolated from microbial extracts. The structures were determined by 1D and 2D NMR techniques and chemical degradation. Compounds 1 similar to 3 and 5 were isolated from a fermentation of Streptomyces sp., while 6 was isolated from a fungal fermentation extract. All five compounds have shown potent inhibitory activity in the inducible nitric oxide synthase (iNOS) assay.

引用

页码：496 / 501

页数：6

共 18 条

[1] RAPID IDENTIFICATION OF ELAIOPHYLIN AND GELDANAMYCIN IN STREPTOMYCES FERMENTATION BROTHS USING CPC COUPLED WITH A PHOTODIODE-ARRAY DETECTOR AND LC-MS METHODOLOGIES [J].