How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemists view

被引：142

作者：

Wu, YK ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2002年 / 35卷 / 05期

关键词：

D O I：

10.1021/ar000080b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The antimalarial. mechanism of qinghaosu (artemisinin) has been a problem since the late 1970s. During the past decade, several molecular level theories were postulated. However, their further development has been very difficult. By looking into the QHS cleavage process and all possible reaction paths available to the resulting transient radicals, the present commentary reveals,those major hidden problems with the existing theories and tries to identify some essential features of the parasiticidal events that may take place within the intraerythrocytic malaria parasite. A seemingly more reasonable theory is also introduced.

引用

页码：255 / 259

页数：5

共 54 条

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