Chlamydia pneumoniae -: An infectious risk factor for atherosclerosis?

被引：236

作者：

Campbell, LA ^{[1
]}

Kuo, CC ^{[1
]}

机构：

[1] Univ Washington, Dept Pathobiol, Seattle, WA 98155 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 01期

关键词：

D O I：

10.1038/nrmicro796

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cardiovascular disease, of which atherosclerosis is an important component, is the leading cause of death in the western world. Although there are well-defined risk factors for atherosclerosis, these factors do not account for all incidences of the disease. Because atherosclerotic processes are typified by chronic inflammatory responses, which are similar to those that are elicited by chronic infection, the role of infection in promoting or accelerating atherosclerosis has received renewed attention. This review focuses on the accumulating evidence that chronic infection with Chlamydia pneumoniae, a ubiquitous human respiratory pathogen, might contribute to atherosclerotic lesion progression.

引用

页码：23 / 32

页数：10

共 109 条

[1] Chlamydia pneumoniae does not increase atherosclerosis in the aortic root of apolipoprotein E-deficient mice
Aalto-Setälä, K
Laitinen, K
Erkkilä, L
Leinonen, M
Jauhiainen, M
Ehnholm, C
Tamminen, M
Puolakkainen, M
Penttilä, I
Saikku, P
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (04) : 578 - 584
[2] [Anonymous], 1984, BACTERIOL
[3] Chlamydia pneumoniae induces tissue factor expression in mouse macrophages via activation of Egr-1 and the MEK-ERK1/2 pathway
Bea, F
Puolakkainen, MH
McMillen, T
Hudson, FN
Mackman, N
Kuo, CC
Campbell, LA
Rosenfeld, ME
[J]. CIRCULATION RESEARCH, 2003, 92 (04) : 394 - 401
[4] PERSISTENT CHLAMYDIAE - FROM CELL-CULTURE TO A PARADIGM FOR CHLAMYDIAL PATHOGENESIS
BEATTY, WL
MORRISON, RP
BYRNE, GI
[J]. MICROBIOLOGICAL REVIEWS, 1994, 58 (04) : 686 - 699
[5] Foam cell formation inhibits growth of Chlamydia pneumoniae but does not attenuate Chlamydia pneumoniae-induced secretion of proinflammatory cytokines
Blessing, E
Kuo, CC
Lin, TM
Campbell, LA
Bea, F
Chesebro, B
Rosenfeld, ME
[J]. CIRCULATION, 2002, 105 (16) : 1976 - 1982
[6] Chlamydia pneumoniae and hyperlipidemia are co-risk factors for atherosclerosis:: Infection prior to induction of hyperlipidemia does not accelerate development of atherosclerotic lesions in C57BL/6J mice
Blessing, E
Campbell, LA
Rosenfeld, ME
Kuo, CC
[J]. INFECTION AND IMMUNITY, 2002, 70 (09) : 5332 - 5334
[7] Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J mice
Blessing, E
Campbell, LA
Rosenfeld, ME
Chough, N
Kuo, CC
[J]. ATHEROSCLEROSIS, 2001, 158 (01) : 13 - 17
[8] Chlamydia pneumoniae induces inflammatory changes in the heart and aorta of normocholesterolemic C57BL/6J mice
Blessing, E
Lin, TM
Campbell, LA
Rosenfeld, ME
Lloyd, D
Kuo, CC
[J]. INFECTION AND IMMUNITY, 2000, 68 (08) : 4765 - 4768
[9] High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors
Boman, J
Söderberg, S
Forsberg, J
Birgander, LS
Allard, A
Persson, K
Jidell, E
Kumlin, U
Juto, P
Waldenström, A
Wadell, G
[J]. JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (01) : 274 - 277
[10] Atherosclerosis in apoE knockout mice infected with multiple pathogens
Burnett, MS
Gaydos, CA
Madico, GE
Glad, SM
Paigen, B
Quinn, TC
Epstein, SE
[J]. JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (02) : 226 - 231

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