HLA class I specific inhibitory receptors

被引:95
作者
Moretta, A
Moretta, L
机构
[1] UNIV GENOA, IST PATOL GEN, I-16132 GENOA, ITALY
[2] UNIV GENOA, CTR BIOTECNOL AVANZATE, LAB IMMUNOPATOL, I-16132 GENOA, ITALY
[3] UNIV GENOA, IST ISTOL & EMBRIOL GEN, I-16132 GENOA, ITALY
[4] UNIV BRESCIA, DIPARTIMENTO SCI BIOMED & BIOTECNOL, BRESCIA, ITALY
关键词
D O I
10.1016/S0952-7915(97)80051-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
All human natural killer cells and some memory T cells express HLA class I receptors, so-called natural killer cell receptors (NKRs), a receptor class that in the past few years has been shown to include several members of the immunoglobulin superfamily and the C-type lectin CD94-NKG2A complex. NKR ligand mediated cross-linking leads to the recruitment and activation of a tyrosine phosphatase involved in downregulating the phosphorylation of effector molecules involved in cell triggering. Thus, NKR engagement leads to the inhibition of different NK and T cell functions.
引用
收藏
页码:694 / 701
页数:8
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