Immune-deficient Drosophila melanogaster:: A model for the innate immune response to human fungal pathogens

被引：100

作者：

Alarco, AM

Marcil, A

Chen, J

Suter, B

Thomas, D

Whiteway, M

机构：

[1] Natl Res Council Canada, Biotechnol Res Inst, Genet Grp, Montreal, PQ H4P 2R2, Canada

[2] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 172卷 / 09期

关键词：

D O I：

10.4049/jimmunol.172.9.5622

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We explored the host-pathogen interactions of the human opportunistic fungus Candida albicans using Drosophila melanogaster. We established that a Drosophila strain devoid of functional Toll receptor is highly susceptible to the human pathogen C albicans. Using this sensitive strain, we have been able to show that a set of specific C. albicans mutants of different virulence in mammalian infection models are also impaired in virulence in Drosophila and remarkably display the same rank order of virulence. This immunodeficient insect model also revealed virulence properties undetected in an immunocompetent murine model of infection. The genetic systems available in both host and pathogen will enable the identification of host-specific components and C albicans genes involved in the host-fungal interplay.

引用

页码：5622 / 5628

页数：7

共 56 条

[1] Caenorhabditis elegans as a host for the study of host-pathogen interactions [J].