The homeotic target gene centrosomin encodes an essential centrosomal component

被引:110
作者
Li, KJ [1 ]
Kaufman, TC [1 ]
机构
[1] INDIANA UNIV, HOWARD HUGHES MED INST, DEPT BIOL, BLOOMINGTON, IN 47405 USA
关键词
D O I
10.1016/S0092-8674(00)81258-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The centrosomin (cnn) gene encodes a protein associated with mitotic centrosomes in Drosophila melanogaster and is a target of homeotic gene regulation. Here we report that CNN is an essential component of the centrosome. Loss of zygotic cnn expression disrupts the development of the second midgut constriction, the gastric caeca, and the nervous system. Embryos that lack maternal as well as zygotic cnn expression display defects in nuclear division, chromosome alignment, and microtubule organization, while adult flies that are mosaic for cnn(-) cells exhibit defects indicative of a block in cell proliferation. We propose that cnn provides an example of homeotic genes directly regulating the accumulation of essential cellular proteins to carry out segment-specific morphogenetic functions.
引用
收藏
页码:585 / 596
页数:12
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