Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted children

被引：32

作者：

Campos, M ^{[1
]}

Jouzdani, E ^{[1
]}

Sempoux, C ^{[1
]}

Buts, JP ^{[1
]}

Reding, R ^{[1
]}

Otte, JB ^{[1
]}

Sokal, EM ^{[1
]}

机构：

[1] Univ Catholique Louvain, Clin St Luc, Dept Pediat, B-1200 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2000年 / 159卷 / 1-2期

关键词：

cryptosporidium; cholangitis; transplant;

D O I：

10.1007/s004310050023

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Three children of a series of 461 pediatric liver transplant recipients developed diffuse cholangitis associated with intestinal cryptosporidium carriage. All three received immunosuppression consisting of tacrolimus and prednisone. Cryprosporidium carriage was treated with paramomycin, while immunosuppression was decreased according to graft tolerance. No other infectious pathogens were found, and no vascular problems were detected. Bile duct anastomosis was reoperated in all three: but biliary cirrhosis developed in one patient, requiring retransplantation. All three patients are alive and well, and free of intestinal parasites on follow-up. Conclusion Cryptosporidium intestinal infection may play a role in some cases of otherwise unexplained cholangiopathies in pediatric liver transplant recipients. This may lead to significant morbidity, including need for retransplantation.

引用

页码：113 / 115

页数：3