Atg5: more than an autophagy factor

被引：110

作者：

Codogno, Patrice

Meijer, Alfred J.

机构：

[1] Univ Paris Sud 11, INSERM, U756, F-92296 Chatenay Malabry, France

[2] Univ Amsterdam, Acad Med Ctr, Dept Biochem Med, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1038/ncb1006-1045

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in addition to its role in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.

引用

页码：1045 / 1047

页数：4

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