Conserved filamentous prophage in Escherichia coli O18:K1:H7 and Yersinia pestis biovar orientalis

被引：56

作者：

Gonzalez, MD ^{[1
]}

Lichtensteiger, CA ^{[1
]}

Caughlan, R ^{[1
]}

Vimr, ER ^{[1
]}

机构：

[1] Univ Illinois, Dept Pathobiol, Lab Sialobiol, Urbana, IL 61802 USA

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 21期

关键词：

D O I：

10.1128/JB.184.21.6050-6055.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Microbial virulence is known to emerge by horizontal gene transfer mechanisms. Here we describe the discovery of a novel filamentous prophage, designated CUS-1, which is integrated into the chromosomal dif homologue of the high-virulence clone Escherichia coli O18:K1:H7. An homologous chromosomal element (CUS-2) in Yersinia pestis biovar orientalis is integrated at the same relative location as CUS-1; both lysogenic E. coli and Y. pestis strains produce particles with properties expected of single-stranded DNA virions. CUSphi is epidemiologically correlated with the emergence of K1 strains with increased virulence and with the Y. pestis biovar responsible for the current (third) plague pandemic.

引用

页码：6050 / 6055

页数：6