Childhood absence epilepsy: Genes, channels, neurons and networks

被引:471
作者
Crunelli, V
Leresche, N
机构
[1] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales
[2] Univ Paris 06, CNRS, UMR 7102, F-75252 Paris, France
基金
英国惠康基金;
关键词
D O I
10.1038/nrn811
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and experimental models, together with neurobiological investigations, have led to important breakthroughs in the identification of candidate genes and loci, and potential pathophysiological mechanisms for this type of epilepsy. Here, we review these results, and compare the human and experimental phenotypes that have been investigated. Continuing efforts and comparisons of this type will help us to elucidate the multigenetic traits and pathophysiology of this form of generalized epilepsy.
引用
收藏
页码:371 / 382
页数:12
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