Tissue engineering of the peripheral nervous system

被引：103

作者：

Carriel, Victor ^{[1
,2
]}

Alaminos, Miguel ^{[1
]}

Garzon, Ingrid ^{[1
]}

Campos, Antonio ^{[1
]}

Cornelissen, Maria ^{[2
]}

机构：

[1] Univ Granada, Dept Histol, Tissue Engn Grp, Ave Madrid 11, Granada 18012, Spain

[2] Univ Ghent, Dept Basic Med Sci, Histol & Tissue Engn Grp, B-9000 Ghent, Belgium

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2014年 / 14卷 / 03期

关键词：

biomaterials; cell-based therapy; graft-based repair; surgical nerve repair; tissue engineering; traumatic nerve injuries; tubulization; TO-SIDE NEURORRHAPHY; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; EXTRACELLULAR-MATRIX COMPONENTS; EPSILON-CAPROLACTONE SCAFFOLDS; BIOABSORBABLE POLYMER TUBES; SCIATIC-NERVE; NEUROTROPHIC FACTOR; SCHWANN-CELLS; GROWTH-FACTOR;

D O I：

10.1586/14737175.2014.887444

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The structure and function of peripheral nerves can be affected by a range of conditions with severe consequences in these patients. Currently, there are several surgical techniques available to treat peripheral nerve defects. Direct repair is the preferred treatment for short nerve gaps, and nerve autografting is the gold standard in critical nerve defects. The autografting is not always available, and the use of allograft, decellularized allograft and nerve conduits are often used with variable success. During the recent years, several outcomes were achieved in peripheral nerve tissue engineering. Promising experimental results have been demonstrated with this novel generation of nerve conduits, mainly composed by biodegradables materials in combination with intraluminal fillers, growth factors and different cell sources.

引用

页码：301 / 318

页数：18

共 205 条

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