Her2/neu expression predicts the response to antiaromatase neoadjuvant therapy in primary breast cancer: Subgroup analysis from celecoxib antiaromatase neoadjuvant trial
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作者:
Zhu, L
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机构:Univ Hong Kong, Hung Chao Hong Integrated Ctr Breast Dis, Dept Surg, Hong Kong, Hong Kong, Peoples R China
Zhu, L
Chow, LWC
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机构:Univ Hong Kong, Hung Chao Hong Integrated Ctr Breast Dis, Dept Surg, Hong Kong, Hong Kong, Peoples R China
Chow, LWC
Loo, WTY
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机构:Univ Hong Kong, Hung Chao Hong Integrated Ctr Breast Dis, Dept Surg, Hong Kong, Hong Kong, Peoples R China
Loo, WTY
Guan, XY
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机构:Univ Hong Kong, Hung Chao Hong Integrated Ctr Breast Dis, Dept Surg, Hong Kong, Hong Kong, Peoples R China
Guan, XY
Toi, M
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机构:Univ Hong Kong, Hung Chao Hong Integrated Ctr Breast Dis, Dept Surg, Hong Kong, Hong Kong, Peoples R China
Toi, M
机构:
[1] Univ Hong Kong, Hung Chao Hong Integrated Ctr Breast Dis, Dept Surg, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
[3] Tokyo Metropolitan Komagome Hosp, Breast Unit, Dept Surg, Tokyo, Japan
Purpose: Many studies suggest that Her2/neu play an important role in neoadjuvant endocrine therapy. This study aimed to determine whether the level of Her2/neu expression in advanced breast cancer changes after antiaromatase neoadjuvant treatment, as well as to identify the relationship between Her2/neu expression and response to this kind of therapy. Experimental Design: Thirty-six postmenopausal patients with hormonal receptor-positive primary breast cancer were included in a study of three monthly cycles of neoadjuvant endocrine therapy with either Aromasin (25 mg daily) or Femara (2.5 mg daily). Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) for Her2/neu were conducted both on pretreatment biopsies and surgical tumors. Results: Using HIC, 5 of 36 (13.9%) of the patients had a Her2/neu overexpression after treatment, as compared with 16 of 36 (44.4%) before. Meanwhile, there was no change in 21 (58.3%) patients, and through FISH, there was a change from amplification to no amplification in 15 (41.7%) patients. The response rate to the treatment was 75% for Her2/neu (+) tumors and 35% for Her2/neu (-) tumors (P = 0.017) while FISH was performed. The response rate was also significantly affected by the decrease in Her2/neu status after the treatment, with 73% of the tumors showing decreased Her2/neu expression and with 38 % of the tumors showing no change of Her2/neu expression (P 0.037). Conclusions: Using both HIC and FISH, advanced breast cancers show statistical evidence of decreasing incidence of Her2/neu expression after antiaromatase neoadjuvant treatment. Our data also suggest that Her2/neu expression and its change during the treatment might be predictive markers for this kind of therapy.
机构:
Univ Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R China
Chow, LWC
Wong, JLN
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机构:Univ Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R China
Wong, JLN
Toi, M
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机构:Univ Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R China
机构:
Univ Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R China
Chow, LWC
Wong, JLN
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机构:Univ Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R China
Wong, JLN
Toi, M
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机构:Univ Hong Kong, Med Ctr, Queen Marys Hosp, Dept Surg,Div Breast Surg, Hong Kong, Hong Kong, Peoples R China