5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

被引：32

作者：

Sulsky, R ^{[1
]}

Robl, JA

Biller, SA

Harrity, TW

Wetterau, J

Connolly, F

Jolibois, K

Kunselman, L

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Discovery Chem, Princeton, NJ 08543 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Metab Dis, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

MTP inhibitors; cyclophosphonates;

D O I：

10.1016/j.bmcl.2004.07.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5067 / 5070

页数：4