Endocytosis and cancer

被引：92

作者：

Polo, S

Pece, S

Di Fiore, PP

机构：

[1] IFOM, I-20139 Milan, Italy

[2] Ist Europeo Oncol, I-20141 Milan, Italy

[3] Univ Milan, Sch Med, I-20122 Milan, Italy

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 02期

关键词：

D O I：

10.1016/j.ceb.2004.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.

引用

收藏

页码：156 / 161

页数：6

相关论文

共 51 条

[41] Signal transduction and endocytosis: Close encounters of many kinds [J].

Sorkin, A ;

von Zastrow, M .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (08) :600-614

[42] Src family kinases in tumor progression and metastasis [J].

Summy, JM ;

Gallick, GE .

CANCER AND METASTASIS REVIEWS, 2003, 22 (04) :337-358

[43] Epithelial-mesenchymal transitions in tumour progression [J].

Thiery, JP .

NATURE REVIEWS CANCER, 2002, 2 (06) :442-454

[44]

TICE DA, 2003, P NATL ACAD SCI USA, V96, P337

[45] SCATTER FACTOR - MOLECULAR CHARACTERISTICS AND EFFECT ON THE INVASIVENESS OF EPITHELIAL-CELLS [J].

WEIDNER, KM ;

BEHRENS, J ;

VANDEKERCKHOVE, J ;

BIRCHMEIER, W .

JOURNAL OF CELL BIOLOGY, 1990, 111 (05) :2097-2108

[46] Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells [J].

Weijzen, S ;

Rizzo, P ;

Braid, M ;

Vaishnav, R ;

Jonkheer, SM ;

Zlobin, A ;

Osborne, BA ;

Gottipati, S ;

Aster, JC ;

Hahn, WC ;

Rudolf, M ;

Siziopikou, K ;

Kast, WM ;

Miele, L .

NATURE MEDICINE, 2002, 8 (09) :979-986

[47] Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling [J].

Wong, ESM ;

Fong, CW ;

Lim, J ;

Yusoff, P ;

Low, BC ;

Langdon, WY ;

Guy, GR .

EMBO JOURNAL, 2002, 21 (18) :4796-4808

[48] Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation [J].

Wu, WJ ;

Tu, S ;

Cerione, RA .

CELL, 2003, 114 (06) :715-725

[49] Molecular and functional analysis of cadherin-based adherens junctions [J].

Yap, AS ;

Brieher, WM ;

Gumbiner, BM .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :119-146

[50] Untangling the ErbB signalling network [J].

Yarden, Y ;

Sliwkowski, MX .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (02) :127-137

← 1 2 3 4 5 6 →