Synchronisation in the beta frequency-band - The bad boy of parkinsonism or an innocent bystander?

被引：102

作者：

Eusebio, Alexandre ^{[1
,2
]}

Brown, Peter ^{[1
]}

机构：

[1] Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England

[2] CHU Timone, Dept Neurol & Movement Disorders, Marseille, France

来源：

EXPERIMENTAL NEUROLOGY | 2009年 / 217卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; OSCILLATORY ACTIVITY; PATHOLOGICAL SYNCHRONIZATION; CEREBRAL-CORTEX; DISEASE; DOPAMINE; MOVEMENT; BRADYKINESIA;

D O I：

10.1016/j.expneurol.2009.02.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M. M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain Stimulation. Exp. Neurol. 215, 20-28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its Suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain Stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1 / 3

页数：3

共 33 条

[1] Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients [J].

Amirnovin, R ;

Williams, ZM ;

Cosgrove, GR ;

Eskandar, EN .

JOURNAL OF NEUROSCIENCE, 2004, 24 (50) :11302-11306

[2] The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation [J].

Bronte-Stewart, Helen ;

Barberini, Crista ;

Koop, Mandy Miller ;

Hill, Bruce C. ;

Henderson, Jairnie M. ;

Wingeier, Brett .

EXPERIMENTAL NEUROLOGY, 2009, 215 (01) :20-28

[3] Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease [J].

Brown, P .

MOVEMENT DISORDERS, 2003, 18 (04) :357-363

[4] Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [J].

Brown, P ;

Oliviero, A ;

Mazzone, P ;

Insola, A ;

Tonali, P ;

Di Lazzaro, V .

JOURNAL OF NEUROSCIENCE, 2001, 21 (03) :1033-1038

[5] Paradoxes of functional neurosurgery: Clues from basal ganglia recordings [J].

Brown, Peter ;

Eusebio, Alexandre .

MOVEMENT DISORDERS, 2008, 23 (01) :12-20

[6] Predictors of effective bilateral subthalamic nucleus stimulation for PD [J].

Charles, PD ;

Van Blercom, N ;

Krack, P ;

Lee, SL ;

Xie, J ;

Besson, G ;

Benabid, AL ;

Pollak, P .

NEUROLOGY, 2002, 59 (06) :932-934

[7] Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery [J].

Chen, CC ;

Pogosyan, A ;

Zrinzo, LU ;

Tisch, S ;

Limousin, P ;

Ashkan, K ;

Yousry, T ;

Hariz, MI ;

Brown, P .

EXPERIMENTAL NEUROLOGY, 2006, 198 (01) :214-221

[8] Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease [J].

Chen, Chiung Chu ;

Litvak, Vladimir ;

Gilbertson, Thomas ;

Kuhn, Andrea ;

Lu, Chin Song ;

Lee, Shih Tseng ;

Tsai, Chon Haw ;

Tisch, Stephen ;

Limousin, Patricia ;

Hariz, Marwan ;

Brown, Peter .

EXPERIMENTAL NEUROLOGY, 2007, 205 (01) :214-221

[9] Deep brain stimulation of the subthalamic nucleus:: A two-edged sword [J].

Chen, Chiung Chu ;

Brucke, Christof ;

Kempf, Florian ;

Kupsch, Andreas ;

Lu, Chin Song ;

Lee, Shih Tseng ;

Tisch, Stephen ;

Limousin, Patricia ;

Hariz, Marwan ;

Brown, Peter .

CURRENT BIOLOGY, 2006, 16 (22) :R952-R953

[10] Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction [J].

Costa, Rui M. ;

Lin, Shih-Chieh ;

Sotnikova, Tatyana D. ;

Cyr, Michel ;

Gainetdinov, Raul R. ;

Caron, Marc G. ;

Nicolelis, Miguel A. L. .

NEURON, 2006, 52 (02) :359-369

← 1 2 3 4 →