The emerging role of the histamine H4 receptor in anti-inflammatory therapy

被引：26

作者：

Lim, Herman D. ^{[1
]}

Smits, Rogier A. ^{[1
]}

Leurs, Rob ^{[1
]}

De Esch, Iwan J. P. ^{[1
]}

机构：

[1] Free Univ Amsterdam, Fac Sci, Div Med Chem, LACDR, NL-1081 HV Amsterdam, Netherlands

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 13期

关键词：

D O I：

10.2174/15680266106061365

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antagonists for the Histamine H-1 receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H-4 receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H-4 receptor as a drug target.

引用

页码：1365 / 1373

页数：9

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