Mitotic exit: The Cdc14 double cross

被引:28
作者
Geymonat, M [1 ]
Jensen, S [1 ]
Johnston, LH [1 ]
机构
[1] Natl Inst Med Res, Div Yeast Genet, London NW7 1AA, England
关键词
D O I
10.1016/S0960-9822(02)00963-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The release of Cdc14 from the nucleolus occurs in two waves in early and late anaphase, controlled by the FEAR and MEN pathways, respectively. Two new papers report the localisation at the spindle pole body of the Cdc14 released in early anaphase and, surprisingly, show that the two pulses of released Cdc14 have opposite effects on MEN activation.
引用
收藏
页码:R482 / R484
页数:3
相关论文
共 20 条
  • [11] Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
    Mailand, N
    Lukas, C
    Kaiser, BK
    Jackson, PK
    Bartek, J
    Lukas, J
    [J]. NATURE CELL BIOLOGY, 2002, 4 (04) : 317 - 322
  • [12] Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p
    Pereira, G
    Manson, C
    Grindlay, J
    Schiebel, E
    [J]. JOURNAL OF CELL BIOLOGY, 2002, 157 (03) : 367 - 379
  • [13] Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae
    Ro, HS
    Song, S
    Lee, KS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) : 5436 - 5441
  • [14] THE YEAST TEM1 GENE, WHICH ENCODES A GTP-BINDING PROTEIN, IS INVOLVED IN TERMINATION OF M-PHASE
    SHIRAYAMA, M
    MATSUI, Y
    TOHE, A
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (11) : 7476 - 7482
  • [15] Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
    Shou, WY
    Seol, JH
    Shevchenko, A
    Baskerville, C
    Moazed, D
    Chen, ZWS
    Jang, J
    Shevchenko, A
    Charbonneau, H
    Deshaies, RJ
    [J]. CELL, 1999, 97 (02) : 233 - 244
  • [16] Cdc5 influences phosphorylation of Netl and disassembly of the RENT complex
    Shou, WY
    Azzam, R
    Chen, SL
    Huddleston, MJ
    Baskerville, C
    Charbonneau, H
    Annan, RS
    Carr, SA
    Deshaies, RJ
    [J]. BMC MOLECULAR BIOLOGY, 2002, 3
  • [17] Separase, polo kinase, the kinetochore protein Slk19 and Spo12 function in a network that controls Cdc14 localization during early anaphase
    Stegmeier, F
    Visintin, R
    Amon, A
    [J]. CELL, 2002, 108 (02) : 207 - 220
  • [18] Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
    Visintin, R
    Hwang, ES
    Amon, A
    [J]. NATURE, 1999, 398 (6730) : 818 - 823
  • [19] The phosphatase Cdc14 triggers mitotic exit by reversal of CDK-dependent phosphorylation
    Visintin, R
    Craig, K
    Hwang, ES
    Prinz, S
    Tyers, M
    Amon, A
    [J]. MOLECULAR CELL, 1998, 2 (06) : 709 - 718
  • [20] Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae
    Yoshida, S
    Asakawa, K
    Toh-E, A
    [J]. CURRENT BIOLOGY, 2002, 12 (11) : 944 - 950