Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

被引：1015

作者：

Nasongkla, Norased

Bey, Erik

Ren, Jimin

Ai, Hua

Khemtong, Chalermchai

Guthi, Jagadeesh Setti

Chin, Shook-Fong

Sherry, A. Dean

Boothman, David A.

Gao, Jinming

机构：

[1] Univ Texas, SW Med Ctr, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Adv Imaging Res Ctr, Dallas, TX 75390 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 11期

关键词：

D O I：

10.1021/nl061412u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide ( SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

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页码：2427 / 2430

页数：4

相关论文

共 20 条

[1] Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes [J].

Ai, H ;

Flask, C ;

Weinberg, B ;

Shuai, X ;

Pagel, MD ;

Farrell, D ;

Duerk, J ;

Gao, JM .

ADVANCED MATERIALS, 2005, 17 (16) :1949-+

[2]

BURKE TG, 1987, MOL PHARMACOL, V31, P552

[3] Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP 1049C) in patients with advanced cancer [J].

Danson, S ;

Ferry, D ;

Alakhov, V ;

Margison, J ;

Kerr, D ;

Jowle, D ;

Brampton, M ;

Halbert, G ;

Ranson, M .

BRITISH JOURNAL OF CANCER, 2004, 90 (11) :2085-2091

[4] Tumor regression by targeted gene delivery to the neovasculature [J].

Hood, JD ;

Bednarski, M ;

Frausto, R ;

Guccione, S ;

Reisfeld, RA ;

Xiang, R ;

Cheresh, DA .

SCIENCE, 2002, 296 (5577) :2404-2407

[5] Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies [J].

Kim, TY ;

Kim, DW ;

Chung, JY ;

Shin, SG ;

Kim, SC ;

Heo, DS ;

Kim, NK ;

Bang, YJ .

CLINICAL CANCER RESEARCH, 2004, 10 (11) :3708-3716

[6] Polymeric micelles for delivery of poorly water-soluble compounds [J].

Kwon, GS .

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2003, 20 (05) :357-403

[7] Molecular Imaging applications in nanomedicine [J].

Li, KCP ;

Pandit, SD ;

Guccione, S ;

Bednarski, MD .

BIOMEDICAL MICRODEVICES, 2004, 6 (02) :113-116

[8] Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin [J].

Matsumura, Y ;

Hamaguchi, T ;

Ura, T ;

Muro, K ;

Yamada, Y ;

Shimada, Y ;

Shirao, K ;

Okusaka, T ;

Ueno, H ;

Ikeda, M ;

Watanabe, N .

BRITISH JOURNAL OF CANCER, 2004, 91 (10) :1775-1781

[9] Nanomedicine: current status and future prospects [J].

Moghimi, SM ;

Hunter, AC ;

Murray, JC .

FASEB JOURNAL, 2005, 19 (03) :311-330

[10] cRGD-functionalized polymer micelles for targeted doxorubicin delivery [J].

Nasongkla, N ;

Shuai, X ;

Ai, H ;

Weinberg, BD ;

Pink, J ;

Boothman, DA ;

Gao, JM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (46) :6323-6327