cRGD-functionalized polymer micelles for targeted doxorubicin delivery

被引：347

作者：

Nasongkla, N ^{[1
]}

Shuai, X ^{[1
]}

Ai, H ^{[1
]}

Weinberg, BD ^{[1
]}

Pink, J ^{[1
]}

Boothman, DA ^{[1
]}

Gao, JM ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Radiat Oncol, Cleveland, OH 44106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 46期

关键词：

antitumor agents; bioorganic chemistry; drug delivery; micelles; peptides;

D O I：

10.1002/anie.200460800

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).

引用

页码：6323 / 6327

页数：5

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