The Constituents of Michelia compressa var. formosana and Their Bioactivities

被引：17

作者：

Chan, Yu-Yi ^{[1
]}

Juang, Shin-Hun ^{[2
]}

Huang, Guan-Jhong ^{[3
]}

Liao, Yu-Ren ^{[4
]}

Chen, Yu-Fon ^{[5
]}

Wu, Chia-Che ^{[6
]}

Chang, Hui-Ting ^{[6
]}

Wu, Tian-Shung ^{[4
]}

机构：

[1] Southern Taiwan Univ Sci & Technol, Dept Biotechnol, Tainan 71005, Taiwan

[2] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan

[3] China Med Univ, Dept Pharm, Taichung 40402, Taiwan

[4] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

[5] Natl Cheng Kung Univ, Dept Life Sci, Tainan 70101, Taiwan

[6] Natl Taiwan Univ, Sch Forestry & Resource Conservat, Taipei 10617, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 06期

关键词：

Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity; CHEMICAL-CONSTITUENTS; CYTOTOXIC PRINCIPLES; ANNONA-CHERIMOLA; ALKALOIDS; STEMS; LIGNANS; LEAVES; PLANTS; ROOT;

D O I：

10.3390/ijms150610926

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 +/- 0.3 and 9.6 +/- 0.5 mu g/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 mu M.

引用

页码：10926 / 10935

页数：10

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