Protective effect of Asarum extract in rats with adjuvant arthritis

被引：46

作者：

Zhang, Wenqiang ^{[1
]}

Zhang, Juan ^{[2
]}

Zhang, Ming ^{[1
]}

Nie, Lin ^{[3
]}

机构：

[1] Shandong Univ, Shandong Qianfoshan Hosp, Dept Orthoped, Jinan 250014, Shandong, Peoples R China

[2] Shandong Univ, Affiliated Hosp 2, Dept Cardiol, Jinan 250033, Shandong, Peoples R China

[3] Shandong Univ, Qilu Hosp, Dept Orthoped, Jinan 250012, Shandong, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2014年 / 8卷 / 05期

关键词：

adjuvant arthritis; rheumatoid arthritis; NF-KAPPA-B; LPS-INDUCED INFLAMMATION; RHEUMATOID-ARTHRITIS; MAPK ACTIVATION; NANOPARTICLES; SYNOVIOCYTES; INHIBITION; PGE(2);

D O I：

10.3892/etm.2014.1941

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The aim of the present study was to investigate the protective effect of Asarum extract on rats with adjuvant arthritis (AA) and to determine the underlying mechanism. An AA model was established by injecting Freund's complete adjuvant into the rats. The degree of toe swelling, arthritis index, spleen index, and the expression levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 were measured. In addition, the underlying molecular mechanism was investigated using murine macrophage-derived RAW 264.7 cells. Asarum extract was found to significantly reduce the severity of arthritis by decreasing hind paw swelling, the arthritis index, the spleen index, and TNF-alpha, IL-1 beta and IL-6 expression levels in plasma. In vitro, Asarum extract inhibited the nuclear factor (NF)-kappa B and mitogen-activated protein kinase (MAPK) signaling pathways. These results indicate that Asarum extract may be a therapeutic agent for AA and may exert an anti-inflammatory effect by mediating the NF-kappa B and MAPK signaling pathways.

引用

页码：1638 / 1642

页数：5

共 26 条

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