AUGUSTUS: a web server for gene finding in eukaryotes

被引：948

作者：

Stanke, M

Steinkamp, R

Waack, S

Morgenstern, B

机构：

[1] Univ Gottingen, Inst Mikrobiol & Genet, D-37077 Gottingen, Germany

[2] Univ Gottingen, Inst Numer & Angew Math, D-37083 Gottingen, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

关键词：

D O I：

10.1093/nar/gkh379

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a www server for AUGUSTUS, a novel software program for ab initio gene prediction in eukaryotic genomic sequences. Our method is based on a generalized Hidden Markov Model with a new method for modeling the intron length distribution. This method allows approximation of the true intron length distribution more accurately than do existing programs. For genomic sequence data from human and Drosophila melanogaster, the accuracy of AUGUSTUS is superior to existing gene-finding approaches. The advantage of our program becomes apparent especially for larger input sequences containing more than one gene. The server is available at http://augustus.gobics.de.

引用

页码：W309 / W312

页数：4

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