Prostaglandin analogs and blood-aqueous barrier integrity: A flare cell meter study

Purpose: To study, with an objective method, inflammation of the anterior segment of the glaucomatous eye after treatment with latanoprost, travoprost and bimatoprost. Materials and Methods: Sixty patients with chronic open-angle glaucoma aged between 38 and 76 years (mean 64.0+/-12.2) were randomly assigned to latanoprost 0.005, travoprost 0.004 and bimatoprost 0.03%. The study period lasted 6 months. Intraocular pressure (IOP) was measured every 2 weeks. We studied the intraocular inflammation before and after 3 and 6 months of therapy with an instrument composed of a HeNe laser beam system, a photomultiplier mounted on a slitlamp microscope and a computer. This flare meter allows objective determination of the flare and the number of cells in the aqueous of the anterior chamber. Results: At the baseline, IOP was 26.4+/-3.6 mm Hg. After 3 months of treatment, mean IOP in the latanoprost group was 17.9+/-0.3 mm Hg (p<0.001) with a mean cellularity of 12.638±3.284 photons/ms (p<0.001). The travoprost group had an IOP of 17.2+/-0.3 mm Hg (p<0.001) with a cellularity of 9.719±1.927 photons/ms (0.001). Finally, IOP in the bimatoprost group was 17.6±0.5 mm Hg (p<0.001) with a cellularity of 6.138+/-1.475 photons/ms (p<0.032). After 6 months of treatment, IOP in the latanoprost group was 18.1±0.3 (p<0.001), in the travoprost group 17.3+/-0.3 (p<0.001) and in the bimatoprost group 17.7±0.5 mm Hg (p<0.001), whereas cellularity was 11.838+/-3.218 (p<0.001), 8.950±3.692 (p<0.001) and 7.617+/-2.603 photons/ms (p<0.001), respectively. After 3 months, the travoprost (p<0.013) and the bimatoprost groups (p<0.001) had less flare compared with the latanoprost group and this remained so even at 6 months. When we compared the travoprost group with the bimatoprost group, we found significantly less flare at 3 months in the bimatoprost group (p<0.001) but not at 6 months (p<0.246). Conclusions: The flare meter analysis shows that the eyes treated with bimatoprost and travoprost have a less significantly broken blood-aqueous barrier and their anterior chamber is also significantly less inflamed. Copyright (C) 2004 S. Karger AG, Basel.