Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata

被引：20

作者：

Aoki, S

Naka, Y

Itoh, T

Furukawa, T

Rachmat, R

Akiyama, S

Kobayashi, M

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Kagoshima Univ, Fac Med, Inst Canc Res, Kagoshima 8908520, Japan

[3] LIPI, Res & Dev Ctr Oceanol, Jakarta 11048, Indonesia

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 06期

关键词：

lembehsterol; thymidine phosphorylase; angiogenesis; sulfated sterol; sponge;

D O I：

10.1248/cpb.50.827

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence.

引用

页码：827 / 830

页数：4

共 16 条

[1] Steroids from sponges: Recent reports [J].