Shaping the genome - restriction-modification systems as mobile genetic elements

被引：84

作者：

Kobayashi, I

Nobusato, A

Kobayashi-Takahashi, N

Uchiyama, I

机构：

[1] Univ Tokyo, Inst Med Sci, Tokyo 1088639, Japan

[2] Natl Inst Basic Biol, Okazaki, Aichi 4448585, Japan

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0959-437X(99)00026-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A restriction enzyme gene is often linked to a modification methylase gene the role of which is to protect a recognition site on DNA from breakage by the former. Loss of some restriction-modification gene complexes leads to cell death through restriction breakage in the genome. Their behavior as genomic parasites/symbionts may explain the distribution of restriction sites and clarify certain aspects of bacterial recombination repair and mutagenesis. A comparison of bacterial genomes supports the hypothesis that restriction-modification gene complexes are mobile elements involved in various genome rearrangements and evolution.

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收藏

页码：649 / 656

页数：8

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