Directed meta-metalation using alkali-metal-mediated zincation

被引：82

作者：

Armstrong, David R.

Clegg, William

Dale, Sophie H.

Hevia, Eva

Hogg, Lorna M.

Honeyman, Gordon W.

Mulvey, Robert E.

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

[2] Newcastle Univ, Sch Nat Sci Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 23期

关键词：

anilides; deprotonation; metalation; sodium; zincation;

D O I：

10.1002/anie.200600720

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Move over directed ortho-metalation, here comes directed meto-metalation. The unprecedented meto-zincation of two anilides by a synergic mixed sodium/zinc dialkyl-amide base is presented. The orientation of the deprotonation of the anilides is remarkably switched to the meta site using this heterometallic mixed-metal system. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3775 / 3778

页数：4

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