Bromine-magnesium exchange of 5-bromo-2-picoline via an organomagnesium complex nBu2iPrMgLi:: a new preparation methodology of functionalized picolines under noncryogenic conditions

被引:14
作者
Kii, S
Akao, A
Iida, T
Mase, T
Yasuda, N
机构
[1] Banyu Pharmaceut Co Ltd, Proc Res, Okazaki, Aichi 4440858, Japan
[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
关键词
D O I
10.1016/j.tetlet.2006.01.095
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The organomagnesium complex "(Bu2PrMgLi)-Pr-i, readily prepared from "BuLi and (PrMgCl)-Pr-i (2:1), is quite efficient for the bromine-magnesium exchange of 5-bromo-2-picoline under noncryogenic conditions (at -10 degrees C). The resulting picolylmagnesium complex reacts with various electrophiles to afford functionalized picolines. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1877 / 1879
页数:3
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