Bromine-magnesium exchange of 5-bromo-2-picoline via an organomagnesium complex nBu2iPrMgLi:: a new preparation methodology of functionalized picolines under noncryogenic conditions

被引：14

作者：

Kii, S

Akao, A

Iida, T

Mase, T

Yasuda, N

机构：

[1] Banyu Pharmaceut Co Ltd, Proc Res, Okazaki, Aichi 4440858, Japan

[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 12期

关键词：

D O I：

10.1016/j.tetlet.2006.01.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The organomagnesium complex "(Bu2PrMgLi)-Pr-i, readily prepared from "BuLi and (PrMgCl)-Pr-i (2:1), is quite efficient for the bromine-magnesium exchange of 5-bromo-2-picoline under noncryogenic conditions (at -10 degrees C). The resulting picolylmagnesium complex reacts with various electrophiles to afford functionalized picolines. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1877 / 1879

页数：3

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