Repair of DNA Lesions Associated With Triplex-Forming Oligonucleotides

被引：56

作者：

Chin, Joanna Y.

Glazer, Peter M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA

来源：

MOLECULAR CARCINOGENESIS | 2009年 / 48卷 / 04期

关键词：

DNA repair; gene targeting; gene modification; interstrand cross-link repair; NUCLEOTIDE EXCISION-REPAIR; INTERSTRAND CROSS-LINKS; CELL-FREE-EXTRACTS; HELIX FORMATION; MAMMALIAN-CELLS; INDUCED RECOMBINATION; PSORALEN ADDUCTS; IN-VITRO; GENE; SEQUENCE;

D O I：

10.1002/mc.20501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triplex-forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence-specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA-reactive agents to specific locations in the genome, or can induce targeted mutagenesis and recombination. There is evidence that third strand binding, alone or with an associated cross-link, is recognized and metabolized by DNA repair factors, particularly the nucleotide excision repair pathway. This review examines the evidence for DNA repair of triplex-associated lesions. (C) 2008 Wiley-Liss, Inc.

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页码：389 / 399

页数：11

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