Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barre syndrome

被引：43

作者：

Ang, CW

Tio-Gillen, AP

Groen, J

Herbrink, P

Jacobs, BC

Van Koningsveld, R

Osterhaus, ADME

Van der Meché, FGA

van Doorn, PA

机构：

[1] Erasmus Med Ctr, Dept Med Microbiol & Infect Dis, NL-3015 GD Rotterdam, Netherlands

[2] Erasmus Med Ctr, Dept Neurol, NL-3015 GD Rotterdam, Netherlands

[3] Erasmus Med Ctr, Dept Immunol, NL-3015 GD Rotterdam, Netherlands

[4] Erasmus Med Ctr, Dept Virol, NL-3015 GD Rotterdam, Netherlands

[5] Diagnost Ctr SSDZ, Dept Immunol & Infect Dis, NL-2600 GA Delft, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 130卷 / 1-2期

关键词：

molecular mimicry; neuropathy; Mycoplasma pneumoniae;

D O I：

10.1016/S0165-5728(02)00209-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with NIP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with NIP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：179 / 183

页数：5

共 23 条

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